Summary: Background: Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy.The EZH2 inhibitor EPZ-6438 was first approved by the US Food and Drug Administration (FDA) in 2020.However, its inadequate anti-cancer activity in solid tumors limits its clinical application.In this study, we utilized the mult
This article contributes to the slowly growing literature on the 1894-1896 Armenian massacres with a microhistory of the events in the city of Harput (Kharpert) on November 11, 1895.Historians have shed light on the structural reasons behind the event and identified Fan Shop - Oilers - Clothing the individuals in charge but the collective aspect of
Although efforts have been directed towards the protection of victims of human trafficking Treats Packaged and smuggling, the existing systems are still flawed and lack more effective ways to provide support, assistance and long-term status to those victims.Several international mechanisms exist, however, the protection and assistance they provide
Abstract Long-term observation of the triboelectric effect has not only proved the feasibility of many novel and useful tribo-devices (e.g., triboelectric nanogenerators), but also constantly motivated the exploration of its mysterious nature.In the pursuit of a comprehensive understanding of how the triboelectric process works, a more accurate des
We present a new algorithm for solving the common problem of flow trapped in closed depressions within digital elevation models, as encountered in many applications relying on flow routing.Unlike other approaches (e.g., the Priority-Flood depression filling algorithm), this solution is based on the explicit computation of the flow paths both within